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University of Graz Natural sciences Institute of Pharmaceutical Sciences News Was Krebszellen schwach macht: Neuer Ansatz im Kampf gegen Therapieresistenz
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Tuesday, 04 March 2025

Was Krebszellen schwach macht: Neuer Ansatz im Kampf gegen Therapieresistenz

A. Koeberle ©Uni Graz/Tzivanopoulos

Andreas Koeberle erforscht die Wirkung verschiedener zytotoxischer Naturstoffe auf Krebszellen

Eine besondere Herausforderung in der Behandlung von Krebserkrankungen sind Therapieresistenzen. Ein internationales Forschungsteam hat nun einen Mechanismus entdeckt, der neue Behandlungsstrategien für Tumore eröffnet, bei denen konventionelle Chemotherapeutika an ihre Grenzen stoßen. „Zytotoxische Wirkstoffe aus der Natur führen zu einer verstärkten Einlagerung mehrfach ungesättigter Fettsäuren in die Membran von Krebszellen. Das macht sie bereits in einem sehr frühen Stadium anfälliger für die Ferroptose, eine Art des Zelltods“, berichtet Andreas Koeberle, Pharmazeut der Uni Graz und Hauptautor der Studie, die soeben im Wissenschaftsjournal Nature Communications erschienen ist.

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