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University of Graz Natural sciences Institute of Pharmaceutical Sciences Research Pharmacognosy Research
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Research at the Intersection of Inflammation, Cancer, and Lipid Signaling

Research Overview ©Uni Graz/Koeberle
©Uni Graz/Koeberle

The Pharmacognosy research group focuses on the molecular mechanisms of phytochemicals at the interface of inflammation, (lipid) metabolism and (lipid) signalling. We use (bio)analytical, biochemical and molecular pharmacological techniques to discover innovative drug targets and to develop phytopharmaceuticals and biogenic lead structures. In addition, natural products are used to elucidate the physiological role of their targets in cellular processes related to chronic inflammation and programmed cell death. A key aspect of our interdisciplinary approach is advanced chromatographic and mass spectrometric bioanalytics of lipids (i.e. targeted lipidomics), which helps to uncover the intricate and largely unexplored links between lipid metabolism, signalling pathways and cellular homeostasis.

Functional (redox) lipidomics
Phytochemical biology and pharmacology

Research Projects

Effects and mechanisms of

Natural substances in immune regulation and stress adaptation

Targeting ferroptosis

at the intersection of cancer and inflammation

Cell fate-determining phospholipids

as signaling molecules with therapeutic potential

Ferroptosis-inhibiting natural products

Dr. Solveigh Koeberle

Epigenetic control of lipid metabolism

in adaptive drug resistance

Natural product- gut microbiome- interactions

PD Dr. Eva-Maria Pferschy-Wenzig

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