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Pharmaceutical Analysis (Schmid, Ortner, Kunert)

Drug and drug analysis

Ao.Univ.-Prof. Mag. Dr.rer.nat. Martin Schmid

Bio sensors

Ao. Univ.-Prof. Mag. pharm. Dr. rer.nat. Astrid Ortner
 

NMR Center
Ass.-Prof. Dr.phil.nat. Dipl.-Chem. Olaf Kunert

Research Summary:

Development of methods for enantiomer separation by High Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE). This topic involves synthesis of new chiral selectors for HPLC , CE and the new principle of capillary electrochromatography (CEC); Synthesis of chiral phases, development of new chiral separation principles; application to the separation of the enantiomers of compounds of biological interest, drugs and pestizides.

Development of Flow-Injection Immunoassays (FIIA). Flow-Injection Immunoassays represent a new, rapid immunoassay technique making use of Flow-Injection Analysis systems. Hetero-and homogeneous assays using fluorescence- and chemiluminescence detection are beeing developed. Application of these systems for pharmaceutical analysis, environmental analysis and diagnostic purposes are under investigation.

The main interest of our research work is focussed on the development of methods for the determination of biological active compounds in the picomole or femtomole range in biological materials. This includes pharmacokinetic studies of drugs and metabolites in blood, plasma, serum and urine as well as pesticide quantification in water and other materials, analysis of cosmetic products, or prostaglandin and phospholipid determination in different human materials. In order to enhance sensitivity and selectivity derivatization agents for flourescence or electrochemical detetion in combination with chromatographic separation techniques are beeing designed. Photolytic processes and recently, problems dealing with clinical pharmacy are under investigation.

Further projects are centered around modern analytics of pumpkin seeds and their oil as well as sterol analysis of eatable oils.

 

Research focus:

Pharmaceutical Analysis:

Design of electrochemical (bio)sensors for determining biologically active substances in complex matrix and as screening tools for diagnostic applications. The sensors are based on carbon paste and screen printed electrodes.

Development of HPLC and FIA methods for the quantification of drugs and their metabolites and/or degradation products within the context of stability tests, quality control and pharmakokinetic studies. Detection is mainly carried out by fluorimetric and electrochemical techniques.

Example: Principal of developed PSAO-biosensors for analyzing biogenic amines in food.
 

Cooperations:

Prof. Dr. Dale Edmondson

Prof. Dr. Kurt Kalcher

Prof. Dr. Peter Macheroux

Prof. Dr. Anton Sadjak

Prof. Dr. Manfred Schubert-Zsilavecz

Dr. Mario Wurglics

 

Clinical Pharmacy

Medicinal product related investigations for improving patient safety in the clinical area.

Example: Investigation of the susceptibility of errors in dispensing and administering of drugs.

Cooperations:

Dr. Ian Rudd

Dr. Lam Sin Hoon

Dr. Ingrid Friedel

Dr. Marianne Leitner

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Contact

Institute of Pharmaceutical Sciences
Universitätsplatz 1/I A-8010 Graz
Pharmaceutical Chemistry Phone:+43 (0)316 380 - 5365
Fax:+43 (0)316 380 - 9846

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