Network Pharmacology (Stelzl)

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From molecular interaction networks to personalized drug treatment

Stelzl, Ulrich, Univ.-Prof. Dipl.-Ing. Dr.rer.nat.                   

Jany-Luig, Evelyne, M.Sc.

Heine Christian Lukas, Mag.pharm. Dr.rer.nat.

Woodsmith, Jonathan, PhD


Ph.D. positions available (FWF funded)

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Announcements of the Institute of Pharmaceutical Sciences

Research summary

The group is focusing on the analysis of molecular interaction networks with the aim to understand the dynamics of molecular networks underlying cellular processes related to human disease. Experimental functional genomics techniques, e.g. HTP Y2H screening, are utilized in combination with biochemical, cell biological and computational methods.

Network biology offers a more comprehensive understanding of biological processes. Advances in systems biology indicate that complex diseases may not be treated effectively by interventions at single drug targets and with single drugs. Network biology will advance our understanding of drug action and will be an important piece in developing individualized medicine. 

Recommended reading on network biology / network pharmacology

Review: Studying post-translational modifications with protein interaction Networks in Current Opinion in Structural Biology. doi: 10.1016/

Viewpoint: Molecular interaction networks in the analyses of sequence variation and proteomics data in Proteomics Clinical Applications doi: 10.1002/prca.201300039 

A new discipline: network science !? An insight commentary at Nature Physics suggests ...  The network takeover by Albert-László Barabási (Boston|Massachusetts)

For starters, a technology feature on interaction mapping free at Nature magazine (2012) ...  The interaction map by Monya Baker (Editor at Nature|Nature Methods)

To get a quick idea about the "interactome" a technology feature at Nature magazine (2010) may be helpful ...  Interactome under construction by Laura Bonetta (Garrett Park|Maryland)  


Updated research records can be found at

pubmed, google scholar, scopus or researcherID.


Recent selected publications

Apelt L, Knockenhauer KE, Leksa NC, Benlasfer N, Schwartz TU, Stelzl U (2016)
Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex.
Mol Cell Proteomics 15:2594.
access the PPI data via INTACT, EBI(IMEx) 

Grossmann A*, Benlasfer N*, Birth P, Hegele A, Wachsmuth F, Apelt L, Stelzl U (2015)
Phospho-tyrosine dependent protein-protein interaction network.
Mol Syst Biol 11:794.
full text open access article
access the PPI data via INTACT, EBI(IMEx)

Stelzl U (2014)
E. coli network upgrade.
Nat Biotechnol 32: 241-243. (N&V)

Woodsmith J, Stelzl U (2014)
Studying post-translational modifications with protein interaction networks.
Curr Opin Struct Biol 24: 34-44. (review)

Woodsmith J, Kamburov A, Stelzl U (2013)
Dual Coordination of Post Translational Modifications in Human Protein Networks.
PLoS Comput Biol 9: e1002933.
full text open access article

Weimann M*, Grossmann A*, Woodsmith J*, Ozkan Z, Birth P, Meierhofer D, Benlasfer N, Valovka T, Timmermann B, Wanker EE, Sauer S, Stelzl U (2013)
A Y2H-seq approach defines the human protein methyltransferase interactome.
Nat Methods 10: 339-342.
access the PPI data via INTACT, EBI(IMEx) 

Hegele A*, Kamburov A*, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, Lührmann R, Stelzl U (2012)
Dynamic Protein-Protein Interaction Wiring of the Human Spliceosome.
Mol Cell 45: 567-580.
full text via Open Archive at Cell press
access the PPI data via INTACT, EBI(IMEx) 

old web page at the MPIMG, Berlin 

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Pharmaceutical Chemistry
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