Network Pharmacology (Stelzl)

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From molecular interaction networks to personalized drug treatment


Stelzl, Ulrich, Univ.-Prof. Dipl.-Ing. Dr.rer.nat.                   

Jany-Luig, Evelyne, M.Sc.

Smolnig, Martin, BSc MSc.

Woodsmith, Jonathan, PhD


News

Ph.D. positions available (FWF funded)

News on uni.on (german only)

Announcements of the Institute of Pharmaceutical Sciences


Research summary

The group is focusing on the analysis of molecular interaction networks with the aim to understand the dynamics of molecular networks underlying cellular processes related to human disease. Experimental functional genomics techniques, e.g. HTP Y2H screening, are utilized in combination with biochemical, cell biological and computational methods.

Network biology offers a more comprehensive understanding of biological processes. Advances in systems biology indicate that complex diseases may not be treated effectively by interventions at single drug targets and with single drugs. Network biology will advance our understanding of drug action and will be an important piece in developing individualized medicine. 


Recommended reading on interaction networks / network biology / network pharmacology:

 

Systematic interaction studies in human disease research, a technology feature free at Nature magazine: Protein maps chart the causes of disease by Marissa Fessenden (Bozeman|Montana)


A new discipline: network science !? An insight commentary at Nature Physics suggests ...  The network takeover by Albert-László Barabási (Boston|Massachusetts)


For starters, a technology feature on interaction mapping free at Nature magazine (2012) ...  The interaction map by Monya Baker (Editor at Nature|Nature Methods)


To get a quick idea about the "interactome" a technology feature at Nature magazine (2010) may be helpful ...  Interactome under construction by Laura Bonetta (Garrett Park|Maryland)  


Publications

Updated research records can be found at

pubmed, google scholar, scopus or researcherID.

    

Recent selected publications

Woodsmith J, Apelt L, Casado-Medrano V, Özkan Z, Timmermann B, Stelzl U (2017)
Protein interaction perturbation profiling at amino-acid resolution.
Nat Methods 14: doi: 10.1038/nmeth.4464.
PMID: 29039417

Corwin T, Woodsmith J, Apelt F, Fontaine JF, Meierhofer D, Helmuth J, Grossmann A, Andrade-Navarro MA, Ballif BA, Stelzl U (2017)
Defining Human Tyrosine Kinase Phosphorylation Networks Using Yeast as an In Vivo Model Substrate.
Cell Syst. 5:128-139.
PMID: 28837810

Apelt L, Knockenhauer KE, Leksa NC, Benlasfer N, Schwartz TU, Stelzl U (2016)
Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex.
Mol Cell Proteomics 15:2594.
PMID: 27194810
access the PPI data via INTACT, EBI(IMEx) 

Grossmann A*, Benlasfer N*, Birth P, Hegele A, Wachsmuth F, Apelt L, Stelzl U (2015)
Phospho-tyrosine dependent protein-protein interaction network.
Mol Syst Biol 11:794.
PMID: 25814554
full text open access article
access the PPI data via INTACT, EBI(IMEx)
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old web page at the MPIMG, Berlin 

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Contact

Institute of Pharmaceutical Sciences
Universitätsplatz 1/IA-8010 Graz

Pharmaceutical Chemistry
+43 (0)316 380 - 5365
+43 (0)316 380 - 9846

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